Methergine (methylergonovine maleate) injection label
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چکیده
DESCRIPTION Methergine (methylergonovine maleate) is a semi-synthetic ergot alkaloid used for the prevention and control of postpartum hemorrhage. Methergine is available in sterile ampuls of 1 mL, containing 0.2 mg methylergonovine maleate for intramuscular or intravenous injection and in tablets for oral ingestion containing 0.2 mg methylergonovine maleate. Tablets Active Ingredient: methylergonovine maleate, USP, 0.2 mg. Inactive Ingredients: acacia, carnauba wax, D&C Red #7, FD&C Blue #1, gelatin special, lactose, maleic acid, mixed parabens, povidone, sodium benzoate, sodium hydroxide, starch, stearic acid, sucrose, talc, and titanium dioxide. Ampuls: 1 mL, clear, colorless solution. Active Ingredient: methylergonovine maleate, USP, 0.2 mg. Inactive Ingredients: maleic acid, 0.10 mg; sodium chloride, 7.0 mg; water for injection, qs to 1 mL. Chemically, methylergonovine maleate is designated as ergoline-8-carboxamide, 9,10-didehydro-N-[1 (hydroxymethyl)propyl]-6-methyl-, [8β(S)]-, (Z)-2-butenedioate (1:1) (salt). Its structural formula is
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Methylergonovine Maleate Injection, USP
CLINICAL PHARMACOLOGY Methylergonovine maleate acts directly on the smooth muscle of the uterus and increases the tone, rate, and amplitude of rhythmic contractions. Thus, it induces a rapid and sustained tetanic uterotonic effect which shortens the third stage of labor and reduces blood loss. The onset of action after I.V. administration is immediate; after I.M. administration, 2 to 5 minutes,...
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Introduction: Almost every one in four women experiences an incomplete abortion in her life. During the twentieth century, uterine contents were evacuated using either forceps or curettage. Re-evaluation of this treatment seems logical. This study was designed to evaluate the results of medical treatment of first trimester incomplete abortion with methyl ergonovine maleate. Methods and Mate...
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Eighteen Postpartum Holstein Friesian (HF) crossbred cows aged between 2nd and 5th lactations were selected and randomly divided into 2 experimental groups viz., group I and II (control). On day 2 Postpartum group I and II cows were treated with an intramuscular injection of 5 mg methyl ergometrine maleate and 5 ml normal saline, respectively. The cervical involution progressed rapidly and on d...
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BACKGROUND Methylergonovine is an ergot alkaloid widely used in postpartum women. It is also an active metabolite of methysergide and previous studies suggest that it could be effective against refractory headache and cluster headache. The purpose of the present study was to assess the potential therapeutic effectiveness of methylergonovine in the emergency treatment of severe migraine. METHO...
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